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Samantha, a human first name originally meaning "listener", may refer to:
- Samantha I Winton, the 12th monarch of the Star Kingdom of Manticore.
- Samantha II Winton, the 14th monarch of the Star Kingdom of Manticore.
- Samantha Adamskos-Winton, Queen Consort in early 16th Century PD.
- Samantha Howell, an officer of the Royal Manticoran Navy.
- Samantha, a treecat also known as "Golden Voice".