Jessica may refer to:
- Lady Jessica Burke, Countess of Green Vale, a Manticoran politician.
- Jessica Challot, an officer in the People's Navy.
- Jessica Dorcett, an officer of the Royal Manticoran Navy.
- Jessica Epstein, another officer of the RMN.
- Jessica Hackett, an officer of the People's Navy.
- Jessica Hauptman, an officer of the RMN Office of Naval Intelligence.
- Jessica Orbach, a Manticoran physician and Third Lord of the Admiralty.
- Jessica Pheriss, an early Sphinxian colonist and treecat adoptee.
- Jessica Stein, a leader of the Renaissance Association.
- HMS Jessica Epps, an Edward Saganami-A-class heavy cruiser of the Royal Manticoran Navy.
- HMS Jessica Rice, an Edward Saganami-C-class heavy cruiser of the RMN.
- Jessica Falls, a waterfall on the planet Sphinx.