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The genetically enhanced "super soldiers" the Confederate government employed in its fight against the Ukrainian Supremacists were sterile by design. In order to gain control of their only means of reproduction, they turned on their own creators and took over the cloning farms they had come from.
The result of the coup was a period of internal struggle that weakened the war effort, while the change in Asian leadership also caused the Europeans to start weaponizing disease strains, while the nations of the Western Hemisphere started to weaponize nanotechnology. (CS3)